Evidence Synthesis Collaboration

‘Evidence Synthesis’ is a key strength of researchers, academics and healthcare professionals working along the North West Coast (NWC).

For many years, review teams have been examining the world’s literature on a variety of health related topics, testing published research against set criteria, summarising results and publishing key findings. The recent award of the CLAHRC NWC has enabled these skilled and experienced individuals to come together and build the NWC Evidence Synthesis Collaboration (ESC).

The vision of the Evidence Synthesis Collaboration is to establish a collaborative, leadership-enhancing programme of activities that contribute to the use of evidence synthesis by CLAHRC NWC partners and encourage consideration of the effects of evidence synthesis on health inequalities.

The goals of the NWC Evidence Synthesis Collaboration are twofold.

- To encourage, facilitate and support specific requests for evidence synthesis from CLAHRC stakeholders, partners and themes to inform policy and/or develop future research projects.

- To support stakeholder and partner teams, through continuing professional development programmes, to address current programme delivery issues.

All forms of data will be considered for use in the synthesis of evidence and application of the full range of synthesis methods will be encouraged (e.g. quantitative, qualitative, realist).

Rapid Review Advisory Panel  

The Integrated Care through Multidisciplinary Teams Rapid Review has been commissioned by CLAHRC NWC to support and inform the CLAHRC NWC Partner Priority Programme. The review is being undertaken by the Evidence Synthesis Theme within CLAHRC NWC and an Advisory Panel has been established to support this process. Read more about the Advisory Panel or view the Frequently Asked Questions.

Systematic Reviews (published) 

Almasi-Hashiani A, Omani-Samani R, Mohammadi M, Amini P, Navid B, Alizadeh A, Morasae EK, Maroufizadeh S. Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis. BMC pregnancy and childbirth. 2019 Dec;19(1):149.
DOI: 10.1186/s12884-019-2291-x

Anderson de Cuevas RM, Saini P, Roberts D, Beaver K, Chandrashekar M, Jain A, Kotas E, Tahir N, Ahmed S, Brown SL. A systematic review of barriers and enablers to South Asian women’s attendance for asymptomatic screening of breast and cervical cancers in emigrant countries. BMJ open. 2018 Jul 1;8(7):e020892.

Dickson R,  Harper LM. Using developmental evaluation principles to build capacity for knowledge mobilisation in health and social care. The Tavistock Institute. 201 Apr 10. https://doi.org/10.1177/1356389019840058

Gibson JM, Ellis RK, Jones SP. ‘Dr Google’Will See You Now! A Review of Online Consumer Information about Anticoagulant and Antithrombotic Medication for Prevention of Recurrent Stroke. Journal of Consumer Health on the Internet. 2019 Jan 2;23(1):1-2.

DOI: 10.1080/15398285.2019.1570800

Gibson JM, Thomas LH, Harrison JJ, Watkins CL, ICONS Project Team and the ICONS Patient, Public and Carer Involvement Groups. Stroke survivors’ and carers’ experiences of a systematic voiding programme to treat urinary incontinence after stroke. Journal of clinical nursing. 2018 May;27(9-10):2041-51.
DOI: 10.1111/jocn.14346

Hanna KL, Hepworth LR, Rowe F. Screening methods for post-stroke visual impairment: a systematic review. Disability and rehabilitation. 2017 Dec 4;39(25):2531-43.
DOI: 10.1080/09638288.2016.1231846

Harper LM, Maden M, Dickson R. Across five levels: The evidence of impact model. Evaluation. 2019 Jun 4:1356389019850844.
DOI: 10.1177%2F1356389019850844

Jukes C, Bjerre A, Gibson J, Coupe J. Pilot study evaluating the feasibility of comparing computer game play with close work during occlusion in children aged 2-7 years with amblyopia. British and Irish Orthoptic Journal. 2019 Jun 17; 15(1):115–124
DOI: 10.22599/bioj.132

Lightbody CE, Clegg A, Patel K, Lucas JC, Storey H, Hackett ML, Watkins DC. Systematic review and meta-analysis of psychosocial risk factors for stroke. In: Seminars in neurology 2017 Jun (Vol. 37, No. 03, pp. 294-306). Thieme Medical Publishers.
DOI: 10.1055/s-0037-1603758 

Maden M. Consideration of health inequalities in systematic reviews: a mapping review of guidance. Systematic reviews. 2016 Dec;5(1):202.
DOI: 10.1186/s13643-016-0379-

Maden M, Cunliffe A, McMahon N, Booth A, Carey GM, Paisley S, Dickson R, Gabbay M. Use of programme theory to understand the differential effects of interventions across socio-economic groups in systematic reviews—a systematic methodology review. Systematic reviews. 2017 Dec;6(1):266. 
DOI 10.1186/s13643-017-0638-9 

Maden M, Kotas E. Evaluating approaches to quality assessment in Library and Information Science LIS systematic reviews: A methodology review. Evidence Based Library and Information Practice. 2016 Jun 20;11(2):149-76.
DOI: 10.18438/B8F630

Maden M, McMahon N, Booth A, Dickson R, Paisley S, Gabbay M. Towards a theory-led meta-framework for considering socioeconomic health inequalities within systematic reviews. Journal of clinical epidemiology. 2018 Aug 17.
DOI: 10.1016/j.jclinepi.2018.08.008

Martin A, Downing J, Maden M, Fleeman N, Alfirevic A, Haycox A, Pirmohamed M. An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. Pharmacogenomics. 2017 Nov;18(16):1541-50. 
DOI: 10.2217/pgs-2017-0076  

McMahon N, Thomson K, Kaner E, Bambra C. Effects of prevention and harm reduction interventions on gambling behaviours and gambling related harm: an umbrella review. Addictive behaviors. 2018 Dec 2.
DOI: 10.1016/j.addbeh.2018.11.048

Peel R, Jones SP, Miller C, Gibson JM. Great expectations? A qualitative study of health professionals’ perspectives on breaking bad news about rehabilitation potential after traumatic brain injury or spinal injury, Disability and Rehabilitation. 2019 Apr 21. 
DOI: 10.1080/09638288.2019.1589586


Theme Successes 

  • Michelle Maden (CLAHRC NWC Evidence Synthesis Theme PHD student) and Eleanor Kotas (formerly CLAHRC NWC Evidence Synthesis Theme Information Specialist) have been nominated by the editor of Evidence Based Library and Information Practice  for 2016 Jesse H. Shera Award (for more detail on this award see: http://librarywriting.blogspot.ca/2016/11/call-for-submissions-jesse-h-shera.html.)
  • Naoimh McMahon was shortlisted for Research Student of the Year Award at the North West Coast Research and Innovation Awards 2017 
  • Evidence for Change (EfC) teams represented CLAHRC NWC when they delivered a workshop at the Internal Festival of Public Health in July 2016. 

Also topping the bill at the event were key note speakers  Professor Sir Michael Marmot and Professor Sir Bruce Keogh, talking about health inequalities and the challenges faced by the NHS. Learning from EfC team members the audience of NHS, Public Health and University staff engaged in an interactive session about how evidence-informed   teams can improve local healthcare.  CLAHRC NWC public advisers Naheed Tahir and Sarah Devlin explained how their teams had involved them as equal peers and the benefits this had given to their projects and to the local community.  NHS team leaders Gill Pope(Lancashire Care) and Christo Chakalov (Liverpool Community Health) explained how their projects were tackling health inequalities and the impressive outcomes the teams have achieved. Finally learning from the audience Ruaraidh Hill Lecturer in Evidence Synthesis gained valuable insights into how the audience would measure impact. Lesley Harper Evidence Synthesis Theme who led the workshop said, ‘it was a wonderful           opportunity to present our work and to showcase the EfC teams’ projects.  The Public Advisers and CLAHRC Partner staff involved did a fantastic job of engaging the audience. It was lovely to see them shine, I’m so proud of them and what they have achieved in such a short space of time.’

Evidence for Change - 2015 Pilot   

Programme Overview 

Poster Presented at UK Evaluation Society Annual Conference (April 2016). 

Developmental Evaluation, Navigating Complexity:"Evidence for Change"- Case Study - A poster presented at UK Evaluation Society Annual Conference 2016.

1) The Way We Were....Now! brought  together Lancashire County Council, East Lancashire Hospitals NHS Trust and residents of Marsden Grange Residential Care Home for the Elderly in Nelson. Demonstrating the outcome of collaborative work aimed at reducing admissions into hospital by improving residents’ mental wellbeing.




    Briefing Paper by Lancashire County Council on its involvement in the above project.


2) Improving Health Outcomes for Young People with Dyslexia (Blackpool Council)



    VIDEO Presentation 

3) A Harm Minimisation Approach in Lancashire (Lancashire Care NHS Foundation Trust)



    VIDEO Presentation

4) Improving bowel cancer screening uptake in the BAME Communities of Liverpool


    VIDEO Presentation 

If you would like to find out more about our work in the area, please contact the Theme Leader, Professor Andrew Clegg