Delivering Personalised Health and Care
Through this theme, we will work to improve self-care by patients, improve access to care in the community, and allow its integration in complex chronic conditions with a personalised approach.
We will provide NHS practitioners and patients with innovations in personalised medicine, medical devices and diagnostic tools that genuinely add value but not cost.
Research will focus on individual variability in drug response, both safety and efficacy with a view to evaluating the mechanisms, and identifying strategies to personalise healthcare in order to optimise drug efficacy and minimise toxicity.
The theme will also have continuous activity to evaluate and optimise the effectiveness of assistive technologies which have the capacity to improve outcomes for patients and to help deliver more efficient healthcare across the wider healthcare system as piloted in the TSB-funded DALLAS programme and specifically the Liverpool-based “More Independence” (Mi) project.
The Theme is currently supporting the design and development of the evaluation of the "Baby Box" initiative (NHS Halton CCG)
Brendan J. Collins, Kevin Cuddy & Antony P. Martin (2017) Assessing the effectiveness and cost-effectiveness of drug intervention programs: UK case study, Journal of Addictive Diseases, 36:1, 5-13,
Downing J., Gleeson H., Clayton PE., Davis JRE., Dimitri P., Wales J., Young B., Callery P. Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study. BMC Endocr Disord. 2017 Jun 15;17(1):33.
Rao C, Sun Myint A, Athanasiou T, Faiz O, Martin AP, Collins B, Smith FM. Avoiding Radical Surgery in Elderly Patients With Rectal Cancer Is Cost-Effective. Dis Colon Rectum. 2017 Jan;60(1):30-42.
Al-Naher, A., Wright, D., Devonald, M. A. J., and Pirmohamed, M. (2017) Renal function monitoring in heart failure – what is the optimal frequency? A narrative review. Br J Clin Pharmacol, doi: 10.1111/bcp.13434
Martin A, Downing J, Maden M, Fleeman N, Alfirevic A, Haycox A, Pirmohamed M: An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review, Pharmacogenomics 2 Nov 2017 https://doi.org/10.2217/pgs-2017-0076
Rao C, et al., A Cost-Effectiveness Analysis of Contact X-ray Brachytherapy for the Treatment of Patients with Rectal Cancer Following a Partial Response to Chemoradiotherapy, Clinical Oncology (2017), https://doi.org/10.1016/j.clon.2017.11.015
Pirmohamed, M (Editorial) Nucleic acid based therapies: developing frontier for precision medicine BMJ 2018;360:k223 doi: https://doi.org/10.1136/bmj.k223
Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Müller, D. J., Dunnenberger, H. M., Chantratita, W., Goldspiel, B., Chen, Y.-T., Carleton, B. C., George, A. L., Mushiroda, T., Klein, T., Gammal, R. S. and Pirmohamed, M. (2018), Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. Clin. Pharmacol. Ther.. doi:10.1002/cpt.1004
Gibson A., Ogese M., Pirmohamed M.; Genetic and nongenetic factors that may predispose individuals to allergic drug reactions Current Opinion in Allergy and Clinical Immunology: August 2018 - Volume 18 - Issue 4 - p 325–332 doi: 10.1097/ACI.0000000000000459
Pennington B., Collins B., Leigh S., Martin AP. et al The cost-effectiveness of seven behavioural interventions to prevent drug misuse in vulnerable populations, International Journal of Drug Policy, Volume 57, 2018, Pages 42-50, ISSN 0955-3959, https://doi.org/10.1016/j.drugpo.2018.03.028